" The development of gastric damage is the result of many aggressive and defensive factors. Among the agents considered for long time as harmful for the stomach was listed capsaicin, the pungent alcaloid of red peppers. However, in the last decades more and more data have arisen proving that capsaicin - as a pharmacologically active agent acting on the vanilliod receptors - has beneficial effects on the gastric mucosa against the aggressive factors. We represent our results obtained with capsaicin in human investigations on the different physiological parameters of the stomach, namely on the gastric secretion and gastric motility. Another member on the aggressive side is the Helicobacter pylori bacterium, considered as one of the main pathogenic factors in the pathogenesis of gastritis and gastric ulceration. We studied the immunological background of the Helicobacter strain-caused infection. We measured the expression of different cyto- and chemokines after infection of a gastric epithelial cell line with Helicobacter felis and pylori. This volume is offered for researchers working in the fields of cell biology, experimental and clinical gastroenterology, molecular biology and immunology. "